The artist has donated the full amount of his £25k honor cash to the trust for venues, which functions to protect the Britain's independent concert spaces.
Fender was given the prize on mid-October as his new release People Watching was declared the best record of the last 12 months.
The musician has chosen to donate the funds to the trust, in recognition of the essential function small stages played in his beginning days.
"I personally couldn't be pursuing my current career if it wasn't for all the shows I played around the North East, and elsewhere, when I was starting out," remarked Sam Fender. "These locations are legendary, but they are struggling."
From early 2023 onward, over 150 of these venues have shut down – roughly 16 percent of the total UK scene.
Recently, well-known musicians like the band Pulp, Coldplay, the singer Katy Perry and Ed Sheeran have all supported the MVT in its efforts to support the industry, by applying a minor surcharge to their ticket costs, which supports local stages.
He also took part, generating in excess of £100,000 on his live tour to help numerous local spots across England, Scotland, and Wales.
The money assisted locations that were facing possible closure due to difficulties arising from flooding, fires and bereavements, as well as licensing issues, conflicts and sound issues.
Other venues received monetary aid in modernizing amenities and technical equipment that directly benefitted performers and concertgoers.
"The idea that money from concerts in major spaces helps the local stages, where it all starts for performers like me, is just logical," the star has said.
He is among several artists to donate his Mercury Prize winnings to charitable organizations.
When the band earned the trophy in the year 1996 for their release the album, frontman Jarvis Cocker announced that the act would give their winnings to the organization the charity.
That year, rapper and singer Ms Dynamite split her prize among multiple charities, including the NSPCC and a Sickle Cell organization.
"And I gave a grand to my local community centre, to their gymnastics class, because I practiced gymnastics when I was growing up and they needed new equipment," she told a publication.
Previously, Ezra Collective contributed their prize money to the community center that nurtured their group, in addition to other independent music bodies.
And 1994 winners the group donated their award to a MS organization after a acquaintance was identified with the condition.
"Winning was quite enough," remarked singer the singer. "The cash was the bonus but we didn't require the cherry, because we had the honor. So our victory touched somebody else's life."
Last week, the Music Venues Trust announced it had rescued two grassroots venues in south-east England, by placing them under community ownership.
The Joiners in that area and the second in Bristol were purchased under the public acquisition program, which is funded by a national body and music fans who acquire "ownership units" in the properties.